The synagogue was built in 1927 by Jews from Monastir in the former Yugoslavia and consecrated by the Chief Rabbi of Thessaloniki, Chaim Raphael Habib. During World War II, the synagogue was saved by being requisitioned by the Red Cross and used as a warehouse. In June 1978, the structure of the building was severely damaged by an earthquake. It was restored by the Greek government and today is used primarily during the high holidays.