The African buffalo is not an ancestor of domestic cattle and is only distantly related to other larger bovines. Owing to its unpredictable nature, which makes it highly dangerous to humans, the African buffalo has never been domesticated,Other than humans, African Cape buffaloes have few predators and are capable of defending themselves against (and killing) lions. Lions do kill and eat buffalo regularly, and in some regions, the buffaloes are the lions' primary prey. It typically takes several lions to bring down a single adult buffalo.The average-sized crocodile typically attacks only old solitary animals and young calves, though they can kill healthy adults.