Christianity arrived in Egypt by the first century CE and was based around the city of Alexandria.At the Council of Nicea in 325, when the first three patriarchates were established, Alexandria was one of them, together with Rome and Antioch. The Egyptian Church ended in isolation. This was mainly due to the uncompromising attitude of the Coptic Patriach, Dioscorus, at the council of Ephesus in 449. Dioscorus challenged the authority of the other patriarchates of Rome, Antioch and Constantinople (the latter was made into a patriarch after the council of Constaninople in 391), about a point of Christian theology, and lost.