The station is served by several long-distance trains linking almost the whole island as the flagship Tren Francés (French Train) Havana-Santa Clara-Santiago. Other long-distance trains, principally departing/ending at Havana Central, link Camagüey to Holguín, Guantánamo, Bayamo, Matanzas, Ciego de Ávila, Las Tunas, Manzanillo and other cities.